Irsogladine maleate (JP17); Gaslon N (TN). Formula. C9H7Cl2N5. C4H4O4. Exact mass. Mol weight. Structure, Mol file KCF file DB search. View and buy high purity Irsogladine maleate from Tocris Bioscience. PDE4 inhibitor; antiulcer agent. Description. You can increase or mucus to protect the stomach, gastric mucosal blood flow better and increase the resistance to gastric acid, I will often heal.

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Solubility Data Irxogladine Max Conc. Chemical structures of six gastric mucosal protectants Irsogladine maleate A. The suppression of intestinal polyp formation in Min mice by irsogladine maleate The administration of 5 irsoglacine 50 ppm irsogladine maleate to Min mice for 8 weeks did not affect body weight, food intake or clinical signs throughout the experimental period.

Mass in vial mg ug ng. In the colon, no remarkable change was observed following treatment with irsogladine maleate.

The representative photos of small intestinal polyps in the three groups are shown in Figure S4. Jpn J Clin Oncol.

The technical data provided above is for guidance lrsogladine. Identification of a pathogen-inducible oxygenase piox as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid. Received Aug 31; Accepted Jan Gene-diet interactions on colorectal cancer risk. Find out more about compound libraries available from Tocris. In fact, to our knowledge, no descriptions of severe side effects of irsogladine maleate treatment have been reported in the literature.

Irsogladine maleate

In this study, we only aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model, and left for future experiments whether the combined treatment of aspirin and gastric mucosal protectants inhibits intestinal carcinogenesis while suppressing the side-effects of aspirin.

For Research Use Only. Among the six protectants, irsogladine maleate clearly inhibited NF-jB and AP-1 transcriptional activity. Your account has been deactivated. Angel P, Karin M.


Further in vitro and in vivo experiments and clinical trials investigating the irsogladone of colon carcinogenesis by irsogladine maleate are needed to provide solid evidence of the chemopreventive effects of maletae maleate in the colon.

As a negative control, consecutive sections were immunostained without exposure to the primary Ab. For example, lipid peroxidation-induced exocyclic DNA adduct levels are significantly increased in the affected organs of cancer-prone subjects suffering from Crohn’s disease, chronic hepatitis, chronic pancreatitis and familial adenomatous polyposis [ 24 ]. Comparing the doses and treatment periods of our study with other reports, irsogladine maleate suppressed the development of intestinal neoplastic lesions stronger than its suppression of other organ-derived neoplastic lesions.

Irsogladine maleate | C13H11Cl2N5O4 – PubChem

You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more. Troxipide and sofalcone had disturbance effects on the negative control, and their data were not included in the analysis Figure 2C and 2E. Creating an account with us makes your shopping experience much easier and faster.

Prevention and intervention trials for colorectal cancer.

Sign Up for Santa Cruz Biotechnology news and announcements. An efficient conversion of carboxylic acids to one-carbon degraded aldehydes via 2-hydroperoxy acids. Based on the reduced levels of reactive carbonyl species RCs in Min mice treated with irsogladine maleate, the mechanisms underlying the suppressive effect of the drug on intestinal tumorigenesis are also discussed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Relative RCs levels detected in liver samples taken from irsogladine maleate-treated mice compared with those of the non-treated mice The comparative RCs profiles of liver samples from 5 A. Nozaki et al Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Libermann TA, Baltimore D. As aspirin is a nonselective and irreversible cyclooxygenase COX -inhibitor, aspirin inhibits platelet aggregation and can reduce thrombosis.


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Irsogladine maleate (CAS 84504-69-8)

Each sample was injected seven times to complete the monitoring of the SRM transitions. Furthermore, the chemopreventive property of irsogladine maleate was examined in a Min mouse model of familial adenomatous polyposis.

Citations for Irsogladine maleate Citations are publications that use Tocris products. Privacy and Cookie Policy Site Map. Moreover, the levels of oxidative stress-related markers, reactive iirsogladine species, in the livers of Min mice were clearly decreased following the administration of irzogladine maleate.

This study aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model. Annu Rev Cell Biol. The areas of the circles represent the intensities of the peaks of the detected RCs relative to that of the IS. We calculated the dose of 5 and 50 ppm that corresponds to a human dose. Cardiovascular Research Product Guide. Immunohistochemical staining of Irsogadine to evaluate the proliferation of intestinal polyps in Min mice The small intestines were fixed, embedded and sectioned as Swiss rolls for further immunohistochemical examination using the avidin—biotin complex immunoperoxidase technique after heating with 10 mM citrate buffer pH 6.

Irsogladine maleate | CAS | SCBT – Santa Cruz Biotechnology

Already have an account? Alpha-oxidation of fatty acids in higher plants. Concentration 1 femtomolar picomolar nanomolar micromolar millimolar molar.